| First Author | Charles RP | Year | 2011 |
| Journal | Cancer Res | Volume | 71 |
| Issue | 11 | Pages | 3863-71 |
| PubMed ID | 21512141 | Mgi Jnum | J:172205 |
| Mgi Id | MGI:5004996 | Doi | 10.1158/0008-5472.CAN-10-4463 |
| Citation | Charles RP, et al. (2011) Mutationally Activated BRAFV600E Elicits Papillary Thyroid Cancer in the Adult Mouse. Cancer Res 71(11):3863-71 |
| abstractText | Mutated BRAF is detected in approximately 45% of papillary thyroid carcinomas (PTC). To model PTC, we bred mice with adult-onset, thyrocyte-specific expression of BRAF(V600E). One month following BRAF(V600E) expression, mice displayed increased thyroid size, widespread alterations in thyroid architecture, and dramatic hypothyroidism. Over 1 year, without any deliberate manipulation of tumor suppressor genes, all mice developed PTC displaying nuclear atypia and marker expression characteristic of the human disease. Pharmacologic inhibition of MEK1/2 led to decreased thyroid size, restoration of thyroid form and function, and inhibition of tumorigenesis. Mice with BRAF(V600E)-induced PTC will provide an excellent system to study thyroid tumor initiation and progression and the evaluation of inhibitors of oncogenic BRAF signaling. Cancer Res; 71(11); 3863-71. (c)2011 AACR. |
