| First Author | Li J | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 9 | Pages | 1521-7 |
| PubMed ID | 19364508 | Mgi Jnum | J:148021 |
| Mgi Id | MGI:3843387 | Doi | 10.1016/j.febslet.2009.04.007 |
| Citation | Li J, et al. (2009) Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy. FEBS Lett 583(9):1521-7 |
| abstractText | Diabetic retinopathy is a chronic low-grade inflammatory disease; however, the mechanisms remain elusive. In the present study, we demonstrated that endoplasmic reticulum (ER) stress was activated in the retina in animal models of diabetes and oxygen-induced retinopathy (OIR). Induction of ER stress by tunicamycin resulted in significantly increased expression of inflammatory molecules in the retina. Inhibition of ER stress by chemical chaperone 4-phenyl butyric acid ameliorated inflammation in cultured human retinal endothelial cells exposed to hypoxia, and in the retinas of diabetic and OIR mice. These findings indicate that ER stress is a potential mediator of retinal inflammation in diabetic retinopathy. |
