| First Author | Zhao L | Year | 2013 |
| Journal | Biochem Biophys Res Commun | Volume | 441 |
| Issue | 1 | Pages | 133-8 |
| PubMed ID | 24129189 | Mgi Jnum | J:211526 |
| Mgi Id | MGI:5575616 | Doi | 10.1016/j.bbrc.2013.10.026 |
| Citation | Zhao L, et al. (2013) Effect of Liraglutide on endoplasmic reticulum stress in diabetes. Biochem Biophys Res Commun 441(1):133-8 |
| abstractText | Endoplasmic reticulum (ER) stress is associated with the development of diabetes. The present study sought to investigate the effect of Liraglutide, a glucagon like peptide 1 analogue, on ER stress in beta-cells. We found that Liraglutide protected the pancreatic INS-1 cells from thapsigargin-induced ER stress and the ER stress associated cell apoptosis, mainly by suppressing the PERK and IRE1 pathways. We further tested the effects of Liraglutide in the Akita mouse, an ER-stress induced type 1 diabetes model. After administration of Liraglutide for 8weeks, p-eIF2alpha and p-JNK were significantly decreased in the pancreas of the Akita mouse, while the treatment showed no significant impact on the levels of insulin of INS-cells. Taken together, our findings suggest that Liraglutide may protect pancreatic cells from ER stress and its related cell death. |
