| First Author | Tyner SD | Year | 2002 |
| Journal | Nature | Volume | 415 |
| Issue | 6867 | Pages | 45-53 |
| PubMed ID | 11780111 | Mgi Jnum | J:73757 |
| Mgi Id | MGI:2156360 | Doi | 10.1038/415045a |
| Citation | Tyner SD, et al. (2002) p53 mutant mice that display early ageing-associated phenotypes. Nature 415(6867):45-53 |
| abstractText | The p53 tumour suppressor is activated by numerous stressors to induce apoptosis, cell cycle arrest, or senescence. To study the biological effects of altered p53 function, we generated mice with a deletion mutation in the first six exons of the p53 gene that express a truncated RNA capable of encoding a carboxy-terminal p53 fragment. This mutation confers phenotypes consistent with activated p53 rather than inactivated p53. Mutant (p53+/m) mice exhibit enhanced resistance to spontaneous tumours compared with wild-type (p53+/+) littermates. As p53+/m mice age, they display an early onset of phenotypes associated with ageing. These include reduced longevity, osteoporosis, generalized organ atrophy and a diminished stress tolerance. A second line of transgenic mice containing a temperature-sensitive mutant allele of p53 also exhibits early ageing phenotypes. These data suggest that p53 has a role in regulating organismal ageing. |
