| First Author | Hirata A | Year | 2006 |
| Journal | Cancer Lett | Volume | 238 |
| Issue | 2 | Pages | 271-83 |
| PubMed ID | 16150539 | Mgi Jnum | J:110174 |
| Mgi Id | MGI:3639544 | Doi | 10.1016/j.canlet.2005.07.022 |
| Citation | Hirata A, et al. (2006) Organ-specific susceptibility of p53 knockout mice to N-bis(2-hydroxypropyl)nitrosamine carcinogenesis. Cancer Lett 238(2):271-83 |
| abstractText | To elucidate which is the major determinant of susceptibility of p53 deficient mice, the carcinogen or the target organ, N-bis(2-hydroxypropyl)nitrosamine was administered to induce tumors in multi-organs. In a 15-week experiment, the incidences of both lung and hepatic vascular tumors were found to be significantly higher in p53 nullizygous (-/-) than in heterozygous (+/-) and wild-type (+/+) mice, indicating universal susceptibility of p53 (-/-) mice. In a 40-week experiment, p53 (+/-) mice showed increased susceptibility only with regard to vascular tumors, coinciding with significantly more frequent (60%) p53 gene mutations, in comparison with lung tumors with their low mutation rate (10.8%) (P<0.005). These results indicate that the target organ may be a more important factor than the carcinogen in determining susceptibility of p53 (+/-) mice. |
