| First Author | Wang B | Year | 2000 |
| Journal | Radiat Res | Volume | 154 |
| Issue | 3 | Pages | 277-82 |
| PubMed ID | 10956433 | Mgi Jnum | J:64384 |
| Mgi Id | MGI:1889161 | Doi | 10.1667/0033-7587(2000)154[0277:arieir]2.0.co;2 |
| Citation | Wang B, et al. (2000) Adaptive response in embryogenesis. III. Relationship to radiation-induced apoptosis and Trp53 gene status. Radiat Res 154(3):277-82 |
| abstractText | We reported previously that a radiation-induced adaptive response existed in the late period of embryogenesis, and that radiation-induced apoptosis in the predigital regions was responsible for digital defects in embryonic ICR mice. To investigate the possible involvement of the Trp53 gene and radiation-induced apoptosis in radiation-induced adaptive responses in embryogenesis, the present study was conducted using Trp53 wild-type (Trp53(+/+)) and Trp53 heterozygous (Trp53(+/-)) embryonic mice of the C57BL/6 strain. The existence of a radioadaptive response in the Trp53(+/+) embryonic mice was demonstrated by irradiating the embryos with 5 or 30 cGy on embryonic day 11 prior to a challenging irradiation at 3 Gy on embryonic day 12. The two conditioning doses at 5 and 30 cGy significantly suppressed the induction of apoptosis by the challenging dose in the predigital regions of limb buds in the Trp53(+/+) embryonic mice, while no such effect was found in the Trp53(+/-) embryonic mice. These findings indicate that induction of a radioadaptive response in embryogenesis is related to Trp53 gene status and the occurrence of radiation-induced apoptosis. |
