| First Author | Hesselager G | Year | 2003 |
| Journal | Cancer Res | Volume | 63 |
| Issue | 15 | Pages | 4305-9 |
| PubMed ID | 12907595 | Mgi Jnum | J:84848 |
| Mgi Id | MGI:2670325 | Citation | Hesselager G, et al. (2003) Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model. Cancer Res 63(15):4305-9 |
| abstractText | INK4a-ARF and p53 inactivation are common but rarely concurrent findings in glioblastoma multiforme. Here we demonstrate that experimental deletion of either tumor suppressor gene cooperates with retrovirally expressed platelet-derived growth factor (PDGF)-B regarding both tumor latency and frequency in a mouse brain tumor model. We find indications of PTEN down-regulation and increased Akt phosphorylation in both types of null tumors (although more prominent in p53-/- tumors) suggesting a possible mechanism for this synergism. This is the first time that the cooperative tumorigenic effects of PDGF-B stimulation and p53 loss of function are demonstrated in an in vivo model, establishing a functional link between two common molecular changes of human secondary glioblastoma multiforme. |
