| First Author | Zheng D | Year | 2008 |
| Journal | Cancer Res | Volume | 68 |
| Issue | 10 | Pages | 3992-8 |
| PubMed ID | 18483286 | Mgi Jnum | J:135029 |
| Mgi Id | MGI:3790270 | Doi | 10.1158/0008-5472.CAN-07-6594 |
| Citation | Zheng D, et al. (2008) The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development. Cancer Res 68(10):3992-8 |
| abstractText | Solar UV irradiation is an important carcinogen that leads to the development of skin cancer, which is the most common human cancer. However, the receptors that mediate UV-induced skin carcinogenesis have not yet been unequivocally identified. Here we showed that UV irradiation directly activates cannabinoid receptors 1 and 2 (CB1/2). Notably, our data indicated that the absence of the CB1/2 receptors in mice results in a dramatic resistance to UVB-induced inflammation and a marked decrease in UVB-induced skin carcinogenesis. A marked attenuation of UVB-induced activation of mitogen-activated protein kinases and nuclear factor- kappaB was associated with CB1/2 deficiency. These data provide direct evidence indicating that the CB1/2 receptors play a key role in UV-induced inflammation and skin cancer development. |
