| First Author | Gunji A | Year | 2006 |
| Journal | Cancer Lett | Volume | 241 |
| Issue | 1 | Pages | 87-92 |
| PubMed ID | 16338061 | Mgi Jnum | J:114595 |
| Mgi Id | MGI:3689475 | Doi | 10.1016/j.canlet.2005.10.003 |
| Citation | Gunji A, et al. (2006) Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts. Cancer Lett 241(1):87-92 |
| abstractText | The impact of poly(ADP-ribose) polymerase-1 (Parp-1)-deficiency on 4-nitroquinoline 1-oxide (4NQO)-induced carcinogenesis was studied in mice with an ICR/129Sv mixed genetic background. Parp-1(+/+), Parp-1(+/-) and Parp-1(-/-) animals given 4NQO for thirty-two weeks at 0.001% in their drinking water developed papillomas and squamous cell carcinomas of the tongue, palate and esophagus, but with no statistically significant variation with the Parp-1 genotype. Thus Parp-1 deficiency does not elevate susceptibility to carcinogenesis induced by a carcinogen which gives rise to bulky DNA lesions. This study also indicated that the ICR/129Sv mixed genetic background is associated with high yield induction of esophageal tumors by 4NQO. |
