| First Author | Fotaki V | Year | 2013 |
| Journal | Dev Biol | Volume | 380 |
| Issue | 2 | Pages | 299-313 |
| PubMed ID | 23624311 | Mgi Jnum | J:199602 |
| Mgi Id | MGI:5503272 | Doi | 10.1016/j.ydbio.2013.04.017 |
| Citation | Fotaki V, et al. (2013) Foxg1 is required to limit the formation of ciliary margin tissue and Wnt/beta-catenin signalling in the developing nasal retina of the mouse. Dev Biol 380(2):299-313 |
| abstractText | The ciliary margin (CM) develops in the peripheral retina and gives rise to the iris and the ciliary body. The Wnt/beta-catenin signalling pathway has been implicated in ciliary margin development. Here, we tested the hypothesis that in the developing mouse retina Foxg1 is responsible for suppressing the Wnt/beta-catenin pathway and restricting CM development. We showed that there is excess CM tissue in Foxg1(-/-) null embryos and this expansion is more pronounced in the nasal retina where Foxg1 normally shows its highest expression levels. Results on expression of a reporter allele for Wnt/beta-catenin signalling and of Lef1, a target of Wnt/beta-catenin signalling, displayed significant upregulation of this pathway in Foxg1(-/-) nulls at embryonic days 12.5 and 14.5. Interestingly, this upregulation was observed specifically in the nasal retina, where normally very few Wnt-responsive cells are observed. These results indicate a suppressive role of Foxg1 on this signalling pathway. Our results reveal a new role of Foxg1 in limiting CM development in the nasal peripheral retina and add a new molecular player in the developmental network involved in CM specification. |
