| First Author | Rommelaere S | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 22 | Pages | 3742-8 |
| PubMed ID | 24140347 | Mgi Jnum | J:205603 |
| Mgi Id | MGI:5545866 | Doi | 10.1016/j.febslet.2013.09.046 |
| Citation | Rommelaere S, et al. (2013) PPARalpha regulates the production of serum Vanin-1 by liver. FEBS Lett 587(22):3742-8 |
| abstractText | The membrane-bound Vanin-1 pantetheinase regulates tissue adaptation to stress. We investigated Vnn1 expression and its regulation in liver. Vnn1 is expressed by centrolobular hepatocytes. Using novel tools, we identify a soluble form of Vnn1 in mouse and human serum and show the contribution of a cysteine to its catalytic activity. We show that liver contributes to Vanin-1 secretion in serum and that PPARalpha is a limiting factor in serum Vnn1 production. Functional PPRE sites are identified in the Vnn1 promoter. These results indicate that serum Vnn1 might be a reliable reporter of PPARalpha activity in liver. |
