| First Author | Saez E | Year | 2003 |
| Journal | Nat Med | Volume | 9 |
| Issue | 10 | Pages | 1265-6 |
| PubMed ID | 12960963 | Mgi Jnum | J:86096 |
| Mgi Id | MGI:2678671 | Doi | 10.1038/nm928 |
| Citation | Saez E, et al. (2003) Genetic deficiency in Pparg does not alter development of experimental prostate cancer. Nat Med 9(10):1265-1266 |
| abstractText | The role of the nuclear peroxisome proliferator-activated receptor (PPAR)-gamma in cancer has been a subject of debate. The identification of loss-of-function mutations in PPARG in colon and prostate tumors has led to the idea that this gene may function as a tumor suppressor. We have directly tested this notion using a mouse model of prostate cancer. Neither hemizygous deletion of Pparg nor complete ablation of Ppara influenced the development of prostate cancer in our experimental context. |
