| First Author | Le May C | Year | 2000 |
| Journal | FEBS Lett | Volume | 475 |
| Issue | 3 | Pages | 163-6 |
| PubMed ID | 10869548 | Mgi Jnum | J:63062 |
| Mgi Id | MGI:1860384 | Doi | 10.1016/s0014-5793(00)01648-3 |
| Citation | Le May C, et al. (2000) Reduced hepatic fatty acid oxidation in fasting PPARalpha null mice is due to impaired mitochondrial hydroxymethylglutaryl-CoA synthase gene expression. FEBS Lett 475(3):163-6 |
| abstractText | Glucose and fatty acid metabolism (oxidation versus esterification) has been measured in hepatocytes isolated from 24 h starved peroxisome proliferator-activated receptor-alpha (PPARalpha) null and wild-type mice. In PPARalpha null mice, the development of hypoglycemia during starvation was due to a reduced capacity for hepatic gluconeogenesis secondary to a 70% lower rate of fatty acid oxidation. This was not due to inappropriate expression of the hepatic CPT I gene, which was similar in both genotypes, but to impaired mitochondrial hydroxymethylglutaryl-CoA synthase gene expression in the PPARalpha null mouse liver. We also demonstrate that hepatic steatosis of fasting PPARalpha null mice was not due to enhanced triglyceride synthesis. |
