| First Author | Bagattin A | Year | 2010 |
| Journal | Proc Natl Acad Sci U S A | Volume | 107 |
| Issue | 47 | Pages | 20376-81 |
| PubMed ID | 21059926 | Mgi Jnum | J:166589 |
| Mgi Id | MGI:4848226 | Doi | 10.1073/pnas.1009176107 |
| Citation | Bagattin A, et al. (2010) Transcriptional coactivator PGC-1alpha promotes peroxisomal remodeling and biogenesis. Proc Natl Acad Sci U S A 107(47):20376-81 |
| abstractText | Mitochondria and peroxisomes execute some analogous, nonredundant functions including fatty acid oxidation and detoxification of reactive oxygen species, and, in response to select metabolic cues, undergo rapid remodeling and division. Although these organelles share some components of their division machinery, it is not known whether a common regulator coordinates their remodeling and biogenesis. Here we show that in response to thermogenic stimuli, peroxisomes in brown fat tissue (BAT) undergo selective remodeling and expand in number and demonstrate that ectopic expression of the transcriptional coactivator PGC-1alpha recapitulates these effects on the peroxisomal compartment, both in vitro and in vivo. Conversely, beta-adrenergic stimulation of PGC-1alpha(-/-) cells results in blunted induction of peroxisomal gene expression. Surprisingly, PPARalpha was not required for the induction of critical biogenesis factors, suggesting that PGC-1alpha orchestrates peroxisomal remodeling through a PPARalpha-independent mechanism. Our data suggest that PGC-1alpha is critical to peroxisomal physiology, establishing a role for this factor as a fundamental orchestrator of cellular adaptation to energy demands. |
