| First Author | Bihan H | Year | 2005 |
| Journal | FEBS Lett | Volume | 579 |
| Issue | 11 | Pages | 2284-8 |
| PubMed ID | 15848159 | Mgi Jnum | J:98237 |
| Mgi Id | MGI:3577683 | Doi | 10.1016/j.febslet.2005.03.020 |
| Citation | Bihan H, et al. (2005) Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARalpha). FEBS Lett 579(11):2284-8 |
| abstractText | This study tests the hypothesis that islet peroxisome proliferator-activated receptor alpha (PPARalpha) influences insulin secretion. Freshly isolated islets of normoglycemic PPARalpha-null mice display no major alteration of glucose-stimulated insulin release. However, after 24 h of culture in high glucose, PPARalpha-null islets exhibit elevated basal insulin secretion and fail to increase insulin mRNA. 24-h culture with palmitate replicates this phenotype in wild-type islets. The data suggest that PPARalpha is needed to ensure appropriate insulin secretory response in situation of short-term hyperglycemia, likely by maintaining islet lipid homeostasis. As such, islet PPARalpha could contribute to delay the progression of type 2 diabetes. |
