| First Author | Oishi K | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 25-26 | Pages | 3639-42 |
| PubMed ID | 18840432 | Mgi Jnum | J:143421 |
| Mgi Id | MGI:3826910 | Doi | 10.1016/j.febslet.2008.09.046 |
| Citation | Oishi K, et al. (2008) Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver. FEBS Lett 582(25-26):3639-42 |
| abstractText | Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that regulates the expression of genes associated with lipid metabolism. Recent studies have suggested that the expression of PPARalpha-dependent fibroblast growth factor 21 (FGF21) plays important roles in adaptation to fasting, such as lipolysis and ketogenesis. We found that a nighttime injection of bezafibrate, a ligand of PPARalpha, effectively induced FGF21 expression, whereas a daytime injection did not affect it. Furthermore, bezafibrate-induced circadian FGF21 expression was abolished in PPARalpha-deficient mice. These observations suggest that bezafibrate-induced circadian FGF21 expression is due to circadian variations in the responsiveness of the PPARalpha system in the liver. |
