| First Author | Kikuchi H | Year | 2023 |
| Journal | Nat Commun | Volume | 14 |
| Issue | 1 | Pages | 3481 |
| PubMed ID | 37328470 | Mgi Jnum | J:347478 |
| Mgi Id | MGI:7492862 | Doi | 10.1038/s41467-023-38958-9 |
| Citation | Kikuchi H, et al. (2023) Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics. Nat Commun 14(1):3481 |
| abstractText | Loss of a kidney results in compensatory growth of the remaining kidney, a phenomenon of considerable clinical importance. However, the mechanisms involved are largely unknown. Here, we use a multi-omic approach in a unilateral nephrectomy model in male mice to identify signaling processes associated with renal compensatory hypertrophy, demonstrating that the lipid-activated transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) is an important determinant of proximal tubule cell size and is a likely mediator of compensatory proximal tubule hypertrophy. |
