| First Author | Liauw J | Year | 2005 |
| Journal | J Neurophysiol | Volume | 94 |
| Issue | 1 | Pages | 878-82 |
| PubMed ID | 15985698 | Mgi Jnum | J:114324 |
| Mgi Id | MGI:3688781 | Doi | 10.1152/jn.01205.2004 |
| Citation | Liauw J, et al. (2005) Calcium-stimulated adenylyl cyclases required for long-term potentiation in the anterior cingulate cortex. J Neurophysiol 94(1):878-82 |
| abstractText | Activity-dependent long-term potentiation (LTP) in the CNS is thought to be important in learning, memory, development, and persistent pain. Here, we report that NMDA receptor-dependent LTP is the major form of long-term plasticity in the anterior cingulate cortex (ACC). In addition to N-methyl-D-aspartate (NMDA) receptors, L-type voltage-gated calcium channels are also required for inducing LTP. Activation of calcium-stimulated adenylyl cyclase subtype 1 (AC1) is essential for the induction of LTP in ACC neurons, while AC8 subunit partially contributes to forskolin-induced potentiation. Our results suggest that calcium-stimulated cAMP-dependent signaling pathways play a critical role in cingulate LTP. |
