Other
14 Authors
- Kwak C,
- Kaang BK,
- Chen T,
- Zhao MG,
- Lu J,
- Kim T,
- Li S,
- Descalzi G,
- Collingridge GL,
- Ko HG,
- Koga K,
- Son J,
- Zhuo M,
- Huganir RL
| First Author | Koga K | Year | 2015 |
| Journal | Neuron | Volume | 85 |
| Issue | 2 | Pages | 377-89 |
| PubMed ID | 25556835 | Mgi Jnum | J:219338 |
| Mgi Id | MGI:5620536 | Doi | 10.1016/j.neuron.2014.12.021 |
| Citation | Koga K, et al. (2015) Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain. Neuron 85(2):377-89 |
| abstractText | Chronic pain can lead to anxiety and anxiety can enhance the sensation of pain. Unfortunately, little is known about the synaptic mechanisms that mediate these re-enforcing interactions. Here we characterized two forms of long-term potentiation (LTP) in the anterior cingulate cortex (ACC); a presynaptic form (pre-LTP) that requires kainate receptors and a postsynaptic form (post-LTP) that requires N-methyl-D-aspartate receptors. Pre-LTP also involves adenylyl cyclase and protein kinase A and is expressed via a mechanism involving hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Interestingly, chronic pain and anxiety both result in selective occlusion of pre-LTP. Significantly, microinjection of the HCN blocker ZD7288 into the ACC in vivo produces both anxiolytic and analgesic effects. Our results provide a mechanism by which two forms of LTP in the ACC may converge to mediate the interaction between anxiety and chronic pain. |
