| First Author | Shan Q | Year | 2008 |
| Journal | J Neurosci | Volume | 28 |
| Issue | 48 | Pages | 12864-7 |
| PubMed ID | 19036980 | Mgi Jnum | J:142502 |
| Mgi Id | MGI:3821636 | Doi | 10.1523/JNEUROSCI.2413-08.2008 |
| Citation | Shan Q, et al. (2008) Type 1 adenylyl cyclase is essential for maintenance of remote contextual fear memory. J Neurosci 28(48):12864-7 |
| abstractText | Although molecular mechanisms for hippocampus-dependent memory have been extensively studied, much less is known about signaling events important for remote memory. Here we report that mice lacking type 1 adenylyl cyclase (AC1) are able to establish and retrieve remote contextual memory but unable to sustain it as long as wild-type mice. Interestingly, mice overexpressing AC1 show superior remote contextual memory even though they exhibit normal hippocampus-dependent contextual memory. These data illustrate that calcium coupling to cAMP contributes to the stability of remote memory and identifies AC1 as a potential drug target site to improve long-term remote memory. |
