| First Author | Ikeya M | Year | 2006 |
| Journal | Development | Volume | 133 |
| Issue | 22 | Pages | 4463-73 |
| PubMed ID | 17035289 | Mgi Jnum | J:115338 |
| Mgi Id | MGI:3691402 | Doi | 10.1242/dev.02647 |
| Citation | Ikeya M, et al. (2006) Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development 133(22):4463-73 |
| abstractText | We here report essential roles of the Bmp-binding protein crossveinless 2 (Cv2; Bmper) in mouse organogenesis. In the null Cv2 mutant mouse, gastrulation occurs normally, but a number of defects are found in Cv2-expressing tissues such as the skeleton. Cartilage differentiation by Bmp4 treatment is reduced in cultured Cv2(-/-) fibroblasts. Moreover, the defects in the vertebral column and eyes of the Cv2(-/-) mouse are substantially enhanced by deleting one copy of the Bmp4 gene, suggesting a pro-Bmp role of Cv2 in the development of these organs. In addition, the Cv2(-/-) mutant exhibits substantial defects in Bmp-dependent processes of internal organ formation, such as nephron generation in the kidney. This kidney hypoplasia is synergistically enhanced by the additional deletion of Kcp (Crim2) which encodes a pro-Bmp protein structurally related to Cv2. This study demonstrates essential pro-Bmp functions of Cv2 for locally restricted signal enhancement in multiple aspects of mammalian organogenesis. |
