| First Author | Biris KK | Year | 2007 |
| Journal | Dev Dyn | Volume | 236 |
| Issue | 11 | Pages | 3167-72 |
| PubMed ID | 17937396 | Mgi Jnum | J:125766 |
| Mgi Id | MGI:3759905 | Doi | 10.1002/dvdy.21342 |
| Citation | Biris KK, et al. (2007) Mouse Ripply2 is downstream of Wnt3a and is dynamically expressed during somitogenesis. Dev Dyn 236(11):3167-72 |
| abstractText | Somites are blocks of mesoderm that form when segment boundaries are periodically generated in the anterior presomitic mesoderm (PSM). Periodicity is thought to be driven by an oscillating Notch-centered segmentation clock, whereas boundaries are spatially positioned by the secreted signaling molecules Wnt3a and Fgf8. We identified the putative transcriptional corepressor Ripply2 as a differentially expressed gene in wild-type and Wnt3a(-/-) embryos. Here, we show that Ripply2 is expressed in the anterior PSM and that it indeed lies downstream of Wnt3a. Dynamic Ripply2 expression in prospective somites S0 and S-I overlaps with the rostral expression of cycling genes in the Notch pathway, suggesting that Ripply2 may be controlled by the segmentation clock. Continued expression of Ripply2 in embryos lacking Hes7, a molecular oscillator in the Notch clock, indicates that Hes7 is not a major regulator of Ripply2. Our data are consistent with Ripply2 functioning as a segment boundary determination gene during mammalian embryogenesis. Developmental Dynamics 236:3167-3172, 2007. Published 2007 Wiley-Liss, Inc. |
