| First Author | Stanton BR | Year | 1990 |
| Journal | Mol Cell Biol | Volume | 10 |
| Issue | 12 | Pages | 6755-8 |
| PubMed ID | 1701023 | Mgi Jnum | J:48400 |
| Mgi Id | MGI:1276434 | Doi | 10.1128/mcb.10.12.6755 |
| Citation | Stanton BR, et al. (1990) Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells. Mol Cell Biol 10(12):6755-8 |
| abstractText | We have disrupted one allele of the N-myc locus in mouse embryonic stem (ES) cells by using homologous recombination techniques and have obtained germ line transmission of null N-myc ES cell lines with transmission of the null N-myc allele to the offspring. The creation of mice with a deficient N-myc allele will allow the generation of offspring bearing null N-myc alleles in both chromosomes and permit study of the role that this proto-oncogene plays in embryonic development. |
