| First Author | Flandin P | Year | 2010 |
| Journal | J Neurosci | Volume | 30 |
| Issue | 8 | Pages | 2812-23 |
| PubMed ID | 20181579 | Mgi Jnum | J:157830 |
| Mgi Id | MGI:4437145 | Doi | 10.1523/JNEUROSCI.4228-09.2010 |
| Citation | Flandin P, et al. (2010) The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons. J Neurosci 30(8):2812-23 |
| abstractText | We show that most globus pallidus neurons, but very few neocortical interneurons, are generated from the ventral medial ganglionic eminence and dorsal preoptic area based on fate mapping using an Shh-Cre allele. The Shh-expressing subpallial lineage produces parvalbumin(+) GABAergic neurons, ChAT(+) cholinergic neurons, and oligodendrocytes. Loss of Nkx2-1 function from the Shh-expressing domain eliminated most globus pallidus neurons, whereas most cortical and striatal interneurons continued to be generated, except for striatal cholinergic neurons. Finally, our analysis provided evidence for a novel cellular component (Nkx2-1(-);Npas1(+)) of the globus pallidus. |
