| First Author | Asgarian Z | Year | 2019 |
| Journal | Stem Cell Reports | Volume | 13 |
| Issue | 5 | Pages | 793-802 |
| PubMed ID | 31631021 | Mgi Jnum | J:359644 |
| Mgi Id | MGI:7788941 | Doi | 10.1016/j.stemcr.2019.09.008 |
| Citation | Asgarian Z, et al. (2019) Hippocampal CA1 Somatostatin Interneurons Originate in the Embryonic MGE/POA. Stem Cell Reports 13(5):793-802 |
| abstractText | Oriens lacunosum-moleculare (O-LM) interneurons constitute 40% of hippocampal interneurons expressing Somatostatin (SST). Recent evidence has indicated a dual origin for these cells in the medial and caudal ganglionic eminences (MGE and CGE), with expression of Htr3a as a distinguishing factor. This is strikingly different from cortical SST interneurons that have a single origin within the MGE/preoptic area (POA). We reassessed the origin of hippocampal SST interneurons using a range of genetic lineage-tracing mice combined with single-cell transcriptomic analysis. We find a common origin for all hippocampal SST interneurons in NKX2-1-expressing progenitors of the telencephalic neuroepithelium and an MGE/POA-like transcriptomic signature for all SST clusters. This suggests that functional heterogeneity within the SST CA1 population cannot be attributed to a differential MGE/CGE genetic origin. |
