| First Author | Kimura S | Year | 1999 |
| Journal | Biochimie | Volume | 81 |
| Issue | 4 | Pages | 321-7 |
| PubMed ID | 10401665 | Mgi Jnum | J:110629 |
| Mgi Id | MGI:3640745 | Doi | 10.1016/s0300-9084(99)80077-7 |
| Citation | Kimura S, et al. (1999) Thyroid-specific enhancer-binding protein/thyroid transcription factor 1 is not required for the initial specification of the thyroid and lung primordia. Biochimie 81(4):321-7 |
| abstractText | Targeted disruption of the homeobox gene T/ebp (Ttf1) in mice results in ablation of the thyroid and pituitary, and severe deformities in development of the lung and hypothalamus. T/ebp is expressed in the thyroid, lung, and ventral forebrain during normal embryogenesis. Examination of thyroid development in T/ebp homozygous null mutant embryos revealed that the thyroid rudiment is initially formed but is eliminated through apoptosis. Absence of T/EBP expression in the lung primordium does not activate apoptosis since a lung tissue, albeit dysmorphic, is nevertheless formed in T/ebp-/- embryos. These results demonstrate that T/EBP is not required for the initial specification of thyroid or lung primordia, but is absolutely essential for the development and morphogenesis of these organs. |
