| First Author | Jacquin TD | Year | 1996 |
| Journal | Neuron | Volume | 17 |
| Issue | 4 | Pages | 747-58 |
| PubMed ID | 8893031 | Mgi Jnum | J:75501 |
| Mgi Id | MGI:2176716 | Doi | 10.1016/s0896-6273(00)80206-8 |
| Citation | Jacquin TD, et al. (1996) Reorganization of pontine rhythmogenic neuronal networks in Krox-20 knockout mice. Neuron 17(4):747-58 |
| abstractText | We have shown previously that the inactivation of the zinc finger gene Krox-20 affects hindbrain segmentation, resulting in the elimination of rhombomeres 3 and 5. We demonstrate here that Krox-20 homozygous mutant mice exhibit abnormally slow respiratory and jaw opening rhythms, indicating that a modification of hindbrain segmentation influences the function of neuronal networks after birth. Central neuronal networks that control respiratory frequency are made predominantly depressant by the elimination of a previously undescribed rhythm-promoting system. Recordings of rhythmic activity from the isolated hindbrain following progressive tissue transections indicate that the reorganization takes place in the caudal pontine reticular formation. The newborn (PO) Krox-20-/- mice, in which apneas are ten times longer than in wild-type animals, may be a valuable model for the study of life-threatening apneas during early infancy. |
