Other
10 Authors
- Li B,
- Roberts AW,
- Voll R,
- Na S,
- Davis RJ,
- Flavell RA,
- Zheng W,
- Yu H,
- Williams DA,
- Ghosh S
| First Author | Li B | Year | 2000 |
| Journal | Science | Volume | 288 |
| Issue | 5474 | Pages | 2219-22 |
| PubMed ID | 10864872 | Mgi Jnum | J:63080 |
| Mgi Id | MGI:1860404 | Doi | 10.1126/science.288.5474.2219 |
| Citation | Li B, et al. (2000) Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. Science 288(5474):2219-22 |
| abstractText | T helper 1 (TH1) cells mediate cellular immunity, whereas TH2 cells potentiate antiparasite and humoral immunity. We used a complementary DNA subtraction method, representational display analysis, to show that the small guanosine triphosphatase Rac2 is expressed selectively in murine TH1 cells. Rac induces the interferon-gamma (IFN-gamma) promoter through cooperative activation of the nuclear factor kappa B and p38 mitogen-activated protein kinase pathways. Tetracycline-regulated transgenic mice expressing constitutively active Rac2 in T cells exhibited enhanced IFN-gamma production. Dominant-negative Rac inhibited IFN-gamma production in murine T cells. Moreover, T cells from Rac2-/- mice showed decreased IFN-gamma production under TH1 conditions in vitro. Thus, Rac2 activates TH1-specific signaling and IFN-gamma gene expression. |
