| First Author | Zhang Y | Year | 2008 |
| Journal | J Neuroimmunol | Volume | 194 |
| Issue | 1-2 | Pages | 115-22 |
| PubMed ID | 18192029 | Mgi Jnum | J:131903 |
| Mgi Id | MGI:3774801 | Doi | 10.1016/j.jneuroim.2007.12.002 |
| Citation | Zhang Y, et al. (2008) Toll-like receptor 4 mediates chronic restraint stress-induced immune suppression. J Neuroimmunol 194(1-2):115-22 |
| abstractText | Stress, either physical or psychological, can have a dramatic impact on the immune system. Little progress, however, has been made in understanding stress-induced immune suppression. We report here that mice subjected to chronic 12-hour daily physical restraint for two days significantly increased the expression of Toll-like receptor 4 (TLR4). Interestingly, TLR4-deficient mice are resistant to stress-induced lymphocyte reduction. In addition, restraint stress caused dramatic decrease in T help 1 (Th1) cytokine IFN-gamma and IL-2 levels but increase in Th2 cytokine IL-4 in wild type mice. Moreover, the restraint stress significantly inhibits changes of Th1 and Th2 cytokines in TLR4-deficient mice compared with the wild type mice. Therefore, stress modulates the immune system through a TLR4-dependent mechanism. |
