| First Author | Cenedeze MA | Year | 2007 |
| Journal | Transplant Proc | Volume | 39 |
| Issue | 2 | Pages | 409-11 |
| PubMed ID | 17362743 | Mgi Jnum | J:124472 |
| Mgi Id | MGI:3721747 | Doi | 10.1016/j.transproceed.2007.01.032 |
| Citation | Cenedeze MA, et al. (2007) The role of toll-like receptor 4 in cisplatin-induced renal injury. Transplant Proc 39(2):409-11 |
| abstractText | BACKGROUND: Toll-like receptors recognize pattern-associated molecules found in pathogens as well as in endogen cells and in matrix degradation products. Despite the effectiveness of cisplatin against various solid tumors the administered dose is limited by its nephrotoxicity, namely, induction of tubular cell apoptosis. Herein, we investigated whether the cell toxicity of cisplatin was mediated by toll-like receptor 4 signaling. METHODS: C3H/He J (Toll-like receptor 4 deficient) and C3H/HePas (control) were treated with cisplatin (20 mg/kg). We evaluated renal function as well as expression of (HO-1) heme oxygenase 1 and MCP-1 mRNAs. RESULTS: Animals deficient in Toll-like receptor 4 showed less renal dysfunction after cisplatin therapy, which was more evident at later time points. Moreover, MCP-1 mRNA expression in kidneys from these animals were lower than controls, mainly at 96 hours after treatment. No differences were seen in HO-1 mRNA expression. CONCLUSIONS: These results suggested that cisplatin-induced renal toxicity is mediated in part though toll-like receptor 4. |
