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Allele : Foxa2<tm1Jrt> forkhead box A2; targeted mutation 1, Janet Rossant
Primary Identifier  MGI:1857725 Allele Type  Targeted
Attribute String  Null/knockout Gene  Foxa2
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
description  Double null mutants for this allele and Gsctm1Bhr are altered in phenotype by embryonic day 8.75, with loss of Shh (sonic hedgehog) expression as well as that of Foxa2 in the notochord and ventral neural tube. In the forebrain, loss of expression of the fibroblast growth factor gene Fgf8 may also occur (J:41809).
molecularNote  The entire coding sequence of the gene was replaced with a neomycin selection cassette.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • HNF-3beta<tm1Jrt>,
  • Foxa2<->,
  • HNF3Beta,
  • Foxa2<->,
  • HNF3Beta<->,
  • HNF3Beta<->,
  • Foxa2<null>,
  • HNF3Beta,
  • Hnf3b<tm1Jrt>,
  • Hnf3b<tm1Jrt>,
  • HNF-3beta-,
  • Foxa2<null>,
  • HNF-3beta<tm1Jrt>,
  • HNF-3beta-
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

23 Publication categories

Trail: Allele




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