| First Author | Purton JF | Year | 2000 |
| Journal | Immunity | Volume | 13 |
| Issue | 2 | Pages | 179-86 |
| PubMed ID | 10981961 | Mgi Jnum | J:64179 |
| Mgi Id | MGI:1888831 | Doi | 10.1016/s1074-7613(00)00018-2 |
| Citation | Purton JF, et al. (2000) Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling. Immunity 13(2):179-86 |
| abstractText | Glucocorticoids are believed to play a role in T cell development and selection, although their precise function is controversial. Glucocorticoid receptor (GR)-deficient mice were used to directly investigate this problem. GR-deficient thymocytes were resistant to dexamethasone-mediated apoptosis, confirming the absence of glucocorticoid responsiveness. An absence of GR signaling had no impact on thymocyte development either in vivo or in vitro. T cell differentiation, including positive selection, was normal as assessed by normal development of CD4+CD8+, alphabetaTCR+CD4+, and alphabetaTCR+CD8+ thymocytes. Negative selection, mediated by the superantigen staphylococcal enterotoxin B (SEB), or anti-CD3/CD28, was also normal in the absence of GR signaling. In contrast to earlier reports, these data demonstrate that GR signaling is not essential for intrathymic T cell development or selection. |
