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Publication : Engrailed 1 mediates correct formation of limb innervation through two distinct mechanisms.

First Author  Huettl RE Year  2015
Journal  PLoS One Volume  10
Issue  2 Pages  e0118505
PubMed ID  25710467 Mgi Jnum  J:242459
Mgi Id  MGI:5905257 Doi  10.1371/journal.pone.0118505
Citation  Huettl RE, et al. (2015) Engrailed 1 mediates correct formation of limb innervation through two distinct mechanisms. PLoS One 10(2):e0118505
abstractText  Engrailed-1 (En1) is expressed in the ventral ectoderm of the developing limb where it plays an instructive role in the dorsal-ventral patterning of the forelimb. Besides its well-described role as a transcription factor in regulating gene expression through its DNA-binding domain, En1 may also be secreted to form an extracellular gradient, and directly impact on the formation of the retinotectal map. We show here that absence of En1 causes mispatterning of the forelimb and thus defects in the dorsal-ventral pathfinding choice of motor axons in vivo. In addition, En1 but not En2 also has a direct and specific repulsive effect on motor axons of the lateral aspect of the lateral motor column (LMC) but not on medial LMC projections. Moreover, an ectopic dorsal source of En1 pushes lateral LMC axons to the ventral limb in vivo. Thus, En1 controls the establishment of limb innervation through two distinct molecular mechanisms.
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