| First Author | Onoue A | Year | 2014 |
| Journal | Neurosci Res | Volume | 88 |
| Pages | 23-7 | PubMed ID | 25149914 |
| Mgi Jnum | J:217514 | Mgi Id | MGI:5614191 |
| Doi | 10.1016/j.neures.2014.08.001 | Citation | Onoue A, et al. (2014) Aberrant fragment of Dab1 protein is present in yotari mouse. Neurosci Res 88:23-7 |
| abstractText | The Reelin-Dab1 pathway plays important roles in the development of central nervous system. In the autosomal recessive mutant mouse yotari, there is a replacement of a part of Dab1 gene with a long interspersed nuclear element fragment, and it was previously suggested that no protein derived from this gene was present. We here show that an aberrant fragment of Dab1 protein (p64/60) is present in the brain of yotari mouse. The amount of p64/60 is relatively abundant in the embryonic stages and decreased in the postnatal ones. Unlike wild-type Dab1 protein, p64/60 is not phosphorylated by Fyn kinase and localizes considerably to the nucleus. These data suggested that some phenotypes of yotari may be attributable to the presence of p64/60. It also raises a caveat that a tissue from yotari is not a perfect control for immunostaining of Dab1 protein. |
