| First Author | Troilo H | Year | 2016 |
| Journal | FEBS Lett | Volume | 590 |
| Issue | 15 | Pages | 2398-407 |
| PubMed ID | 27391803 | Mgi Jnum | J:235060 |
| Mgi Id | MGI:5792740 | Doi | 10.1002/1873-3468.12287 |
| Citation | Troilo H, et al. (2016) Mammalian tolloid proteinases: role in growth factor signalling. FEBS Lett 590(15):2398-407 |
| abstractText | Tolloid proteinases are essential for tissue patterning and extracellular matrix assembly. The members of the family differ in their substrate specificity and activity, despite sharing similar domain organization. The mechanisms underlying substrate specificity and activity are complex, with variation between family members, and depend on both multimerization and substrate interaction. In addition, enhancers, such as Twisted gastrulation (Tsg), promote cleavage of tolloid substrate, chordin, to regulate growth factor signalling. Although Tsg and mammalian tolloid (mTLD) are involved in chordin cleavage, no interaction has been detected between them, suggesting Tsg induces a change in chordin to increase susceptibility to cleavage. All members of the tolloid family bind the N terminus of latent TGFbeta-binding protein-1, providing support for their role in TGFbeta signalling. |
