| First Author | Ma D | Year | 2011 |
| Journal | J Biol Chem | Volume | 286 |
| Issue | 6 | Pages | 4302-9 |
| PubMed ID | 21131362 | Mgi Jnum | J:169486 |
| Mgi Id | MGI:4941101 | Doi | 10.1074/jbc.M110.140202 |
| Citation | Ma D, et al. (2011) A novel role of periostin in postnatal tooth formation and mineralization. J Biol Chem 286(6):4302-9 |
| abstractText | Periostin plays multiple functions during development. Our previous work showed a critical role of this disulfide-linked cell adhesion protein in maintenance of periodontium integrity in response to occlusal load. In this study, we attempted to address whether this mechanical response molecule played a direct role in postnatal tooth development. Our key findings are 1) periostin is expressed in preodontoblasts, and odontoblasts; and the periostin-null incisor displayed a massive increase in dentin formation after mastication; 2) periostin is also expressed in the ameloblast cells, and an enamel defect is identified in both the adult-null incisor and molar; 3) deletion of periostin leads to changes in expression profiles of many non-collagenous protein such as DSPP, DMP1, BSP, and OPN in incisor dentin; 4) the removal of a biting force leads to reduction of mineralization, which is partially prevented in periostin-null mice; and 6) both in vitro and in vivo data revealed a direct regulation of periostin by TGF-beta1 in dentin formation. In conclusion, periostin plays a novel direct role in controlling postnatal tooth formation, which is required for the integrity of both enamel and dentin. |
