| First Author | Tang B | Year | 1998 |
| Journal | Nat Med | Volume | 4 |
| Issue | 7 | Pages | 802-7 |
| PubMed ID | 9662371 | Mgi Jnum | J:78174 |
| Mgi Id | MGI:2183671 | Doi | 10.1038/nm0798-802 |
| Citation | Tang B, et al. (1998) Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency. Nat Med 4(7):802-7 |
| abstractText | Components of the transforming growth factor-beta (TGF-beta) signal pathway function as classic tumor suppressors, but the role of the TGF-betas themselves is less clear. Here we show that mice heterozygous for deletion of the TGF-beta1 gene express only 10-30% of wild-type TGF-beta1 protein levels. Although grossly normal, these mice have a subtly altered proliferative phenotype, with increased cell turnover in the liver and lung. Treatment of these mice with chemical carcinogens resulted in enhanced tumorigenesis when compared with wild-type littermates. However, tumors in the heterozygous mice did not lose the remaining wild-type TGF-beta1 allele, indicating that the TGF-beta1 ligand is a new form of tumor suppressor that shows true haploid insufficiency in its ability to protect against tumorigenesis. |
