| First Author | Letterio JJ | Year | 1994 |
| Journal | Science | Volume | 264 |
| Issue | 5167 | Pages | 1936-8 |
| PubMed ID | 8009224 | Mgi Jnum | J:18881 |
| Mgi Id | MGI:67103 | Doi | 10.1126/science.8009224 |
| Citation | Letterio JJ, et al. (1994) Maternal rescue of transforming growth factor-beta 1 null mice. Science 264(5167):1936-8 |
| abstractText | Maternal sources of transforming growth factor-beta 1 (TGF-beta 1) are shown here to contribute to the normal appearance and perinatal survival of TGF-beta 1 null newborn mice. Labeled TGF-beta 1 crossed the placenta and was recovered intact from various tissues after oral administration to mouse pups. TGF beta-1 protein was also detected in cells recovered from breast milk. In immunohistochemical analyses, TGF-beta 1 null embryos and null newborn pups born to TGF-beta 1 heterozygotes stained positive for TGF-beta 1, whereas those born to a null female were negative and had severe cardiac abnormalities. These results suggest an important role for maternal sources of TGF-beta 1 during development and, more generally, provide evidence for maternal rescue of targeted gene disruption in the fetus. |
