| First Author | Yaswen L | Year | 1996 |
| Journal | Blood | Volume | 87 |
| Issue | 4 | Pages | 1439-45 |
| PubMed ID | 8608234 | Mgi Jnum | J:31430 |
| Mgi Id | MGI:78938 | Doi | 10.1182/blood.v87.4.1439.bloodjournal8741439 |
| Citation | Yaswen L, et al. (1996) Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse. Blood 87(4):1439-45 |
| abstractText | Targeted disruption of the transforming growth factor-beta 1 (TGF-beta 1) gene in mice results in the development of a massive multifocal inflammatory disease in many tissues. Because no detectable pathogen was identified, we examined whether autoimmune mechanisms played a role in initiating or maintaining the inflammatory disease. The serum of TGF-beta 1 knockout mice contained elevated titers of antibodies to nuclear antigens (ssDNA, dsDNA, Sm, and RNP) as well as reactivity against the 16/6 idiotype (16/6 Id). In addition, Ig deposits were detected in renal glomeruli of TGF- beta 1 knockout mice. Transplantation of TGF-beta 1 knockout hematopoietic cells into normal irradiated recipients resulted in a similar profile of autoantibody production as well as in the induction of inflammatory lesions. Our results describe autoimmune activity that ensues when the TGF-beta 1 cytokine is absent. |
