| First Author | Nugent P | Year | 1999 |
| Journal | Int J Dev Biol | Volume | 43 |
| Issue | 6 | Pages | 567-70 |
| PubMed ID | 10610030 | Mgi Jnum | J:106284 |
| Mgi Id | MGI:3617997 | Citation | Nugent P, et al. (1999) The role of RXR-alpha in retinoic acid-induced cleft palate as assessed with the RXR-alpha knockout mouse. Int J Dev Biol 43(6):567-70 |
| abstractText | Treatment of pregnant mice with retinoic acid (RA) in mid-gestation produces cleft palate and limb defects in the fetuses. RXR-alpha has been previously shown to mediate the teratogenic effects of RA in the limb. In this study, we show that RXR-alpha is also involved in retinoid-induced palatal clefting. Treatment of RXR-alpha knockout mice with a teratogenic dose of RA on gestation day 11 or 12 induces cleft palate at a lower frequency than that seen in wild-type animals. |
