| First Author | Wasseff SK | Year | 2011 |
| Journal | Neurobiol Dis | Volume | 42 |
| Issue | 3 | Pages | 506-13 |
| PubMed ID | 21396451 | Mgi Jnum | J:172877 |
| Mgi Id | MGI:5009168 | Doi | 10.1016/j.nbd.2011.03.003 |
| Citation | Wasseff SK, et al. (2011) Cx32 and Cx47 mediate oligodendrocyte:astrocyte and oligodendrocyte:oligodendrocyte gap junction coupling. Neurobiol Dis 42(3):506-13 |
| abstractText | In addition to the extensive gap junction coupling between astrocytes themselves, oligodendrocytes are thought to be exclusively coupled to astrocytes (O:A coupling) via heterotypic gap junctions composed of Cx47:Cx43 and Cx32:Cx30. We used fluorescent dyes to examine functional coupling in acute slices from the cerebra of mice lacking Cx32 and/or Cx47. In the corpus callosum, unexpectedly, oligodendrocytes appeared to be directly and exclusively coupled to other oligodendrocytes (O:O coupling), and electron microscopy revealed gap junctions between adjacent oligodendrocytes. O:O coupling was more affected in mice lacking Cx32 than in mice lacking Cx47. In the neocortex, oligodendrocytes appeared to be directly and exclusively coupled to astrocytes; Cx47, but not Cx32, was required for O:A coupling. |
