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Publication : The estrogen receptor beta agonist diarylpropionitrile (DPN) inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways.

First Author  Mancuso M Year  2011
Journal  Cancer Lett Volume  308
Issue  2 Pages  197-202
PubMed ID  21636213 Mgi Jnum  J:173607
Mgi Id  MGI:5049795 Doi  10.1016/j.canlet.2011.05.004
Citation  Mancuso M, et al. (2011) The estrogen receptor beta agonist diarylpropionitrile (DPN) inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways. Cancer Lett 308(2):197-202
abstractText  Gender-related differences in medulloblastoma (MB) development have been reported with a higher incidence in males (slightly above 60%) than in females, female gender being also a significantly favorable prognostic factor in MB. The present study focused on the evaluation of the mechanisms by which estrogens protect against MB formation. To this end, we used a well characterized mouse model of MB
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