| First Author | Obayashi Y | Year | 2013 |
| Journal | Biochem Biophys Res Commun | Volume | 437 |
| Issue | 1 | Pages | 146-50 |
| PubMed ID | 23810393 | Mgi Jnum | J:205324 |
| Mgi Id | MGI:5544561 | Doi | 10.1016/j.bbrc.2013.06.056 |
| Citation | Obayashi Y, et al. (2013) Impaired lipid accumulation in the liver of Tsc2-heterozygous mice during liver regeneration. Biochem Biophys Res Commun 437(1):146-50 |
| abstractText | Tuberin is a negative regulator of mTOR pathway. To investigate the function of tuberin during liver regeneration, we performed 70% hepatectomy on wild-type and Tsc2+/- mice. We found the tuberin phosphorylation correlated with mTOR activation during early liver regeneration in wild-type mice. However, liver regeneration in the Tsc2+/- mice was not enhanced. Instead, the Tsc2+/- livers failed to accumulate lipid bodies, and this was accompanied by increased mortality. These findings suggest that tuberin plays a critical role in liver energy balance by regulating hepatocellular lipid accumulation during early liver regeneration. These effects may influence the role of mTORC1 on cell growth and proliferation. |
