| First Author | Rehrauer H | Year | 2018 |
| Journal | Oncogene | Volume | 37 |
| Issue | 20 | Pages | 2645-2659 |
| PubMed ID | 29507420 | Mgi Jnum | J:262381 |
| Mgi Id | MGI:6160657 | Doi | 10.1038/s41388-018-0153-z |
| Citation | Rehrauer H, et al. (2018) How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations. Oncogene 37(20):2645-2659 |
| abstractText | Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor cells, cytokines, and growth factors accumulated in the peritoneal lavage. Transcriptome profiling revealed YAP/TAZ activation in inflamed mesothelium with further activation in tumors, paralleled by increased levels of cells with nuclear YAP/TAZ. Arg1 was one of the highest upregulated genes in inflamed tissue and tumor. Inflamed tissue showed increased levels of single-nucleotide variations, with an RNA-editing signature, which were even higher in the tumor samples. Subcutaneous injection of asbestos-treated, but tumor-free mice with syngeneic mesothelioma tumor cells resulted in a significantly higher incidence of tumor growth when compared to naive mice supporting the role of the environment in tumor progression. |
