| First Author | Sohier P | Year | 2018 |
| Journal | Pigment Cell Melanoma Res | Volume | 31 |
| Issue | 3 | Pages | 423-431 |
| PubMed ID | 29224244 | Mgi Jnum | J:335433 |
| Mgi Id | MGI:7469926 | Doi | 10.1111/pcmr.12677 |
| Citation | Sohier P, et al. (2018) A histopathological classification system of Tyr::NRAS(Q61K) murine melanocytic lesions: A reproducible simplified classification. Pigment Cell Melanoma Res 31(3):423-431 |
| abstractText | Genetically engineered mouse models offer essential opportunities to investigate the mechanisms of initiation and progression in melanoma. Here, we report a new simplified histopathology classification of mouse melanocytic lesions in Tyr::NRAS(Q)(61K) derived models, using an interactive decision tree that produces homogeneous categories. Reproducibility for this classification system was evaluated on a panel of representative cases of murine melanocytic lesions by pathologists and basic scientists. Reproducibility, measured as inter-rater agreement between evaluators using a modified Fleiss' kappa statistic, revealed a very good agreement between observers. Should this new simplified classification be adopted, it would create a robust system of communication between researchers in the field of mouse melanoma models. |
