| First Author | Mohankumar KM | Year | 2015 |
| Journal | Nat Genet | Volume | 47 |
| Issue | 8 | Pages | 878-87 |
| PubMed ID | 26075792 | Mgi Jnum | J:231851 |
| Mgi Id | MGI:5775254 | Doi | 10.1038/ng.3323 |
| Citation | Mohankumar KM, et al. (2015) An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes. Nat Genet 47(8):878-87 |
| abstractText | Cancers are characterized by non-random chromosome copy number alterations that presumably contain oncogenes and tumor-suppressor genes (TSGs). The affected loci are often large, making it difficult to pinpoint which genes are driving the cancer. Here we report a cross-species in vivo screen of 84 candidate oncogenes and 39 candidate TSGs, located within 28 recurrent chromosomal alterations in ependymoma. Through a series of mouse models, we validate eight new ependymoma oncogenes and ten new ependymoma TSGs that converge on a small number of cell functions, including vesicle trafficking, DNA modification and cholesterol biosynthesis, identifying these as potential new therapeutic targets. |
