| First Author | Cascalho M | Year | 1998 |
| Journal | Science | Volume | 279 |
| Issue | 5354 | Pages | 1207-10 |
| PubMed ID | 9469811 | Mgi Jnum | J:124315 |
| Mgi Id | MGI:3721324 | Doi | 10.1126/science.279.5354.1207 |
| Citation | Cascalho M, et al. (1998) Mismatch repair co-opted by hypermutation. Science 279(5354):1207-10 |
| abstractText | Mice homozygous for a disrupted allele of the mismatch repair gene Pms2 have a mutator phenotype. When this allele is crossed into quasi-monoclonal (QM) mice, which have a very limited B cell repertoire, homozygotes have fewer somatic mutations at the immunoglobulin heavy chain and lambda chain loci than do heterozygotes or wild-type QM mice. That is, mismatch repair seems to contribute to somatic hypermutation rather than stifling it. It is suggested that at immunoglobulin loci in hypermutable B cells, mismatched base pairs are 'corrected' according to the newly synthesized DNA strand, thereby fixing incipient mutations instead of eliminating them. |
