| First Author | Atlasi Y | Year | 2016 |
| Journal | Eur J Cancer | Volume | 68 |
| Pages | 114-124 | PubMed ID | 27750112 |
| Mgi Jnum | J:301080 | Mgi Id | MGI:6504959 |
| Doi | 10.1016/j.ejca.2016.09.012 | Citation | Atlasi Y, et al. (2016) The role of S100a4 (Mts1) in Apc- and Smad4-driven tumour onset and progression. Eur J Cancer 68:114-124 |
| abstractText | INTRODUCTION: S100a4 is a calcium-binding protein belonging to the family of S100-proteins, highly expressed in different stromal cell types. S100A4 has been reported as a prognostic marker in colorectal cancer in association with tumour progression and metastasis. METHODS: In this study, we analysed the in vivo role of S100a4 in intestinal tumour initiation and progression using different transgenic and knockout mouse models. RESULTS: We found that genetic ablation or overexpression of S100a4 in both Apc- and Smad4-mutant mice do not affect tumour initiation in the intestinal tract. In contrast, S100a4 epithelial overexpression in Apc(1638N/+)/KRAS(V12G) mice increases the dissemination of intestinal tumour cells to the liver, in agreement with its role in tumour metastasis. Moreover, we report a novel role for S100a4 in desmoid formation where S100a4 deficiency results in a significant reduction of the tumour burden characteristic of the Apc(1638N) model. In agreement with these results, S100a4 appears to be co-expressed together with mesenchymal stem cell (MSC) markers in desmoid tumours from Apc(1638N/+) mice, as well as from sporadic and hereditary human desmoids. CONCLUSION: Our data provide the first report on the in vivo role of S100a4 in intestinal tumourigenesis and describe a new role for S100a4 in the aetiology of desmoids formation. |
