| First Author | Sonoshita M | Year | 2011 |
| Journal | Cancer Cell | Volume | 19 |
| Issue | 1 | Pages | 125-37 |
| PubMed ID | 21251616 | Mgi Jnum | J:168065 |
| Mgi Id | MGI:4881841 | Doi | 10.1016/j.ccr.2010.11.008 |
| Citation | Sonoshita M, et al. (2011) Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling. Cancer Cell 19(1):125-37 |
| abstractText | Metastasis is responsible for most cancer deaths. Here, we show that Aes (or Grg5) gene functions as an endogenous metastasis suppressor. Expression of Aes was decreased in liver metastases compared with primary colon tumors in both mice and humans. Aes inhibited Notch signaling by converting active Rbpj transcription complexes into repression complexes on insoluble nuclear matrix. In tumor cells, Notch signaling was triggered by ligands on adjoining blood vessels, and stimulated transendothelial migration. Genetic depletion of Aes in Apc(Delta716) intestinal polyposis mice caused marked tumor invasion and intravasation that were suppressed by Notch signaling inhibition. These results suggest that inhibition of Notch signaling can be a promising strategy for prevention and treatment of colon cancer metastasis. |
