| First Author | Sansom OJ | Year | 2004 |
| Journal | Genes Dev | Volume | 18 |
| Issue | 12 | Pages | 1385-90 |
| PubMed ID | 15198980 | Mgi Jnum | J:90759 |
| Mgi Id | MGI:3044547 | Doi | 10.1101/gad.287404 |
| Citation | Sansom OJ, et al. (2004) Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev 18(12):1385-90 |
| abstractText | Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise mechanism of this suppression remains to be defined. Using a novel inducible Ahcre transgenic line in conjunction with a loxP-flanked Apc allele we, show that loss of Apc acutely activates Wnt signaling through the nuclear accumulation of beta-catenin. Coincidentally, it perturbs differentiation, migration, proliferation, and apoptosis, such that Apc-deficient cells maintain a 'crypt progenitor-like' phenotype. Critically, for the first time we confirm a series of Wnt target molecules in an in vivo setting and also identify a series of new candidate targets within the same setting. |
